产品描述： Amphiregulin expression is induced by phorbol ester, estrogen, androgen, and other EGFR ligands. In vitro, amphiregulin

functions as an autocrine growth stimulator to drive proliferation of colon carcinoma cells, normal and oncogene-transformed

mammary epithelial cells, cervical carcinoma cells, prostate cancer cells, and keratinocytes. Amphiregulin is important in the

development of human placenta and murine mammary gland. It is reportedly overexpressed in human cancers of breast,

colon, stomach and pancreas.

Function: Ligand of the EGF receptor/EGFR. Autocrine growth factor as well as a mitogen for a broad range of target cells including

astrocytes, Schwann cells and fibroblasts.