品牌： bioss

品名： Rabbit Anti-NMNAT2 antibody

规格： 100ul

产品描述：

This gene product belongs to the nicotinamide mononucleotide adenylyltransferase (NMNAT) enzyme family, members

of which catalyze an essential step in NAD (NADP) biosynthetic pathway. Unlike the other human family member, which

is localized to the nucleus, and is ubiquitously expressed; this enzyme is cytoplasmic, and is predominantly expressed in

the brain. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Function:

Catalyzes the formation of NAD(+) from nicotinamide mononucleotide (NMN) and ATP. Can also use the deamidated form;

nicotinic acid mononucleotide (NaMN) as substrate but with a lower efficiency. Cannnot use triazofurin monophosphate (TrMP)

as substrate. Also catalyzes the reverse reaction, i.e. the pyrophosphorolytic cleavage of NAD(+). For the pyrophosphorolytic

activity prefers NAD(+), NADH and NAAD as substrates and degrades nicotinic acid adenine dinucleotide phosphate (NHD) less

effectively. Fails to cleave phosphorylated dinucleotides NADP(+), NADPH and NAADP(+).